La recuperación de una lesión traumática de la médula espinal (TSCI) es un desafío debido a la capacidad regenerativa limitada del sistema nervioso central para restaurar las células, la mielina y las conexiones neuronales. La terapia celular, particularmente con células madre mesenquimales (MSC), es muy prometedora para el tratamiento con TSCI....
In recent decades, growth factors have attracted a lot of attention in the study of the pathogenesis of various diseases and conditions because they play a crucial role in the processes of growth, development, and maintenance of cell populations. Growth factors are biologically active polypeptides that function as regulatory signals controlling...
xtracellular vesicles (EVs) represent cell-specific carriers of bioactive cargos that can be of importance in either physiological or pathological processes. Frequently, EVs are seen as intercellular communication vehicles, but it has become more and more evident that their usefulness can vary from circulating biomarkers for an early disease...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing an ongoing pandemic of coronavirus disease 2019 (Covid-19). Effective therapies are required for the treatment of patients with severe stages of the disease. Mesenchymal stem cells (MSCs) have been evaluated in numerous clinical trials, but present challenges, such as...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has caused a global pandemic since late 2019 that resulted in more than 360 million population infection. Among them, less than 7% of infected individuals develop severe or critical illness. Mass vaccination has been carried out, but reinfection and vaccine breakthrough cases...
Mesenchymal stem cells (MSC) are involved in the regeneration of the different missing or compromised periodontal tissues. MSC-derived small extracellular vesicles (sEV) have recently been explored as a favorable substitution for stem cell therapy, as they are capable of producing therapeutic effects comparable to those of their parent cells, with...
La Esclerosis Múltiple es una enfermedad autoinmune y neurodegenerativa crónica de base inflamatoria que afecta a la sustancia gris y blanca del sistema nervioso central. Se caracteriza por la presencia de lesiones focales desmielinizantes y afectación difusa del tejido nervioso aparentemente normal, siendo la discapacidad consecuencia de la...
Exosomes are extracellular vesicles formed by various donor cells that regulate gene expression and cellular function in recipient cells. Exosomes derived from mesenchymal stem cells (MSC-Exos) perform the regulatory function of stem cells by transporting proteins, nucleic acids, and lipids. Intervertebral disc degeneration (IDD) is one of the main...
Ingeniería de tejido ha sido definida como una ciencia interdisciplinaria cuyo fin es la síntesis de materiales que logren mejorar o a restaurar el tejido dañado con el fin de establecer terapias alternativas para tratamientos en caso de pérdida de tejido o fallas de órganos esenciales, ya que los trasplantes están frecuentemente limitados por la...
